The first trip into a new biome should teach you the terrain and threats, not carry every valuable item you own.
Use stronger food than for routine chores
A new biome is a poor place to discover that your normal food set is the limiting factor.
Repair before leaving
Avoid adding equipment durability to the list of unknowns.
Create a recovery plan
A nearby fallback point can turn a death from a major setback into a short recovery.
Treat the first trip as reconnaissance
Learn threats, routes and resources before trying to maximize the haul.